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Developmental Cell 2021 56:3, 383-397.e8
A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane
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Cell Stem Cell 2021 28:2, 315-330.e5
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Science 2021 371:6527, eaba6500
Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
Sai Ma, Bing Zhang, Lindsay M. LaFave, Andrew S. Earl, Zachary Chiang, Yan Hu, Jiarui Ding, Alison Brack, Vinay K. Kartha, Tristan Tay, Travis Law, Caleb Lareau, Ya-Chieh Hsu, Aviv Regev, Jason D. Buenrostro
Cell 2020 183:4, 1103-1116.e20
Defining Transcriptional Signatures of Human Hair Follicle Cell States
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Journal of Investigative Dermatology 2020 140:4, 764-773.e4
Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
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Nature Communications 2020 11:1,
Second-Strand Synthesis-Based Massively Parallel scRNA-Seq Reveals Cellular States and Molecular Features of Human Inflammatory Skin Pathologies
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Immunity 2020 53:4, 878-894.e7
Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes
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eLife 2020 9:,
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Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing
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Cell Stem Cell 2020 27:3, 396-412.e6
Single cell transcriptomics of human epidermis identifies basal stem cell transition states
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Nature Communications 2020 11:1,
Mechanisms of stretch-mediated skin expansion at single-cell resolution
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Nature 2020 584:7820, 268-273
Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma
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Cell 2020 182:2, 497-514.e22
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis
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Immunity 2020 53:1, 204-216.e10
Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development
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Hair-bearing human skin generated entirely from pluripotent stem cells
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Nature 2020 582:7812, 399-404
Single-Cell RNA Sequencing Reveals a Dynamic Stromal Niche That Supports Tumor Growth
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Cell Reports 2020 31:7, 107628
Single-cell RNA-seq reveals lineage-specific regulatory changes of fibroblasts and vascular endothelial cells in keloid
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Nature Cell Biology 2020 22:6, 640-650
Defining the Design Principles of Skin Epidermis Postnatal Growth
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Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis
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Journal of Allergy and Clinical Immunology 2020 146:5, 1056-1069
Single-cell transcriptomes of the human skin reveal age-related loss of fibroblast priming
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Communications Biology 2020 3:1,
Dysfunction of Hair Follicle Mesenchymal Progenitors Contributes to Age-Associated Hair Loss
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Developmental Cell 2020 53:2, 185-198.e7
Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics
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Cell Reports 2020 30:11, 3932-3947.e6
The Molecular Anatomy of Mouse Skin during Hair Growth and Rest
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Cell Stem Cell 2020 26:3, 441-457.e7
Circadian control of interferon-sensitive gene expression in murine skin
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Proceedings of the National Academy of Sciences 2020 117:11, 5761-5771
Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis
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Journal of Allergy and Clinical Immunology 2020 145:6, 1615-1628
Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report
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Nature Medicine 2020 26:2, 236-243
Deciphering the functional heterogeneity of skin fibroblasts using single‐cell RNA sequencing
Vera Vorstandlechner, Maria Laggner, Polina Kalinina, Werner Haslik, Christine Radtke, Lisa Shaw, Beate Maria Lichtenberger, Erwin Tschachler, Hendrik Jan Ankersmit, Michael Mildner
The FASEB Journal 2020 34:3, 3677-3692
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation
Yi-Ling Chen, Tomas Gomes, Clare S. Hardman, Felipe A. Vieira Braga, Danuta Gutowska-Owsiak, Maryam Salimi, Nicki Gray, David A. Duncan, Gary Reynolds, David Johnson, Mariolina Salio, Vincenzo Cerundolo, Jillian L. Barlow, Andrew N.J. McKenzie, Sarah A. Teichmann, Muzlifah Haniffa, Graham Ogg
The Journal of Experimental Medicine 2020 217:3,
Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors
Dan Xue, Tracy Tabib, Christina Morse, Robert Lafyatis
Journal of Dermatological Science 2020 97:1, 41-49
Differential expression of α6 and β1 integrins reveals epidermal heterogeneity at single‐cell resolution
Weiya He, Jinguo Ye, Huiyi Xu, Yangsheng Lin, Yingfeng Zheng
Journal of Cellular Biochemistry 2020 121:3, 2664-2676
A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Michal Slyper, Caroline B. M. Porter, Orr Ashenberg, Julia Waldman, Eugene Drokhlyansky, Isaac Wakiro, Christopher Smillie, Gabriela Smith-Rosario, Jingyi Wu, Danielle Dionne, Sébastien Vigneau, Judit Jané-Valbuena, Timothy L. Tickle, Sara Napolitano, Mei-Ju Su, Anand G. Patel, Asa Karlstrom, Simon Gritsch, Masashi Nomura, Avinash Waghray, Satyen H. Gohil, Alexander M. Tsankov, Livnat Jerby-Arnon, Ofir Cohen, Johanna Klughammer, Yanay Rosen, Joshua Gould, Lan Nguyen, Matan Hofree, Peter J. Tramontozzi, Bo Li, Catherine J. Wu, Benjamin Izar, Rizwan Haq, F. Stephen Hodi, Charles H. Yoon, Aaron N. Hata, Suzanne J. Baker, Mario L. Suvà, Raphael Bueno, Elizabeth H. Stover, Michael R. Clay, Michael A. Dyer, Natalie B. Collins, Ursula A. Matulonis, Nikhil Wagle, Bruce E. Johnson, Asaf Rotem, Orit Rozenblatt-Rosen, Aviv Regev
Nature Medicine 2020 26:5, 792-802
Construction of a human cell landscape at single-cell level
Xiaoping Han, Ziming Zhou, Lijiang Fei, Huiyu Sun, Renying Wang, Yao Chen, Haide Chen, Jingjing Wang, Huanna Tang, Wenhao Ge, Yincong Zhou, Fang Ye, Mengmeng Jiang, Junqing Wu, Yanyu Xiao, Xiaoning Jia, Tingyue Zhang, Xiaojie Ma, Qi Zhang, Xueli Bai, Shujing Lai, Chengxuan Yu, Lijun Zhu, Rui Lin, Yuchi Gao, Min Wang, Yiqing Wu, Jianming Zhang, Renya Zhan, Saiyong Zhu, Hailan Hu, Changchun Wang, Ming Chen, He Huang, Tingbo Liang, Jianghua Chen, Weilin Wang, Dan Zhang, Guoji Guo
Nature 2020 581:7808, 303-309
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing
Salah Mahmoudi, Elena Mancini, Lucy Xu, Alessandra Moore, Fereshteh Jahanbani, Katja Hebestreit, Rajini Srinivasan, Xiyan Li, Keerthana Devarajan, Laurie Prélot, Cheen Euong Ang, Yohei Shibuya, Bérénice A. Benayoun, Anne Lynn S. Chang, Marius Wernig, Joanna Wysocka, Michael T. Longaker, Michael P. Snyder, Anne Brunet
Nature 2019 574:7779, 553-558
A pooled single-cell genetic screen identifies regulatory checkpoints in the continuum of the epithelial-to-mesenchymal transition
José L. McFaline-Figueroa, Andrew J. Hill, Xiaojie Qiu, Dana Jackson, Jay Shendure, Cole Trapnell
Nature Genetics 2019 51:9, 1389-1398
A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage
Amnon Sharir, Pauline Marangoni, Rapolas Zilionis, Mian Wan, Tomas Wald, Jimmy K. Hu, Kyogo Kawaguchi, David Castillo-Azofeifa, Leo Epstein, Kyle Harrington, Pierfrancesco Pagella, Thimios Mitsiadis, Christian W. Siebel, Allon M. Klein, Ophir D. Klein
Nature Cell Biology 2019 21:9, 1102-1112
Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome
Eduardo Soares, Quan Xu, Qingqing Li, Jieqiong Qu, Yuxuan Zheng, Henriette H. M. Raeven, Karina O. Brandao, Isabelle Petit, Willem M. R. van den Akker, Simon J. van Heeringen, Daniel Aberdam, Fuchou Tang, Huiqing Zhou
Proceedings of the National Academy of Sciences 2019 116:35, 17361-17370
Epigenomics and Single-Cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis
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Cancer Discovery 2019 9:10, 1406-1421
Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells
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Cell Reports 2019 27:12, 3657-3671.e4
Transcriptional bursts explain autosomal random monoallelic expression and affect allelic imbalance
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Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways
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Nature Immunology 2019 20:7, 915-927
Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors
Alyxzandria M. Gaydosik, Tracy Tabib, Larisa J. Geskin, Claire-Audrey Bayan, James F. Conway, Robert Lafyatis, Patrizia Fuschiotti
Clinical Cancer Research 2019 25:14, 4443-4454
Single-cell RNA sequencing reveals cell type-specific HPV expression in hyperplastic skin lesions
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Virology 2019 537:, 14-19
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Nature Communications 2019 10:1,
Dermal Condensate Niche Fate Specification Occurs Prior to Formation and Is Placode Progenitor Dependent
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Developmental Cell 2019 48:1, 32-48.e5
Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis
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Developmental Cell 2019 48:1, 17-31.e6
The single-cell transcriptional landscape of mammalian organogenesis
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Nature 2019 566:7745, 496-502
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
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Cell 2018 175:6, 1575-1590.e22
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Nature 2018 563:7730, 197-202
Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution
Jeffrey B. Cheng, Andrew J. Sedgewick, Alex I. Finnegan, Paymann Harirchian, Jerry Lee, Sunjong Kwon, Marlys S. Fassett, Justin Golovato, Matthew Gray, Ruby Ghadially, Wilson Liao, Bethany E. Perez White, Theodora M. Mauro, Thaddeus Mully, Esther A. Kim, Hani Sbitany, Isaac M. Neuhaus, Roy C. Grekin, Siegrid S. Yu, Joe W. Gray, Elizabeth Purdom, Ralf Paus, Charles J. Vaske, Stephen C. Benz, Jun S. Song, Raymond J. Cho
Cell Reports 2018 25:4, 871-883
Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations during Wound Healing
Simon Joost, Tina Jacob, Xiaoyan Sun, Karl Annusver, Gioele La Manno, Inderpreet Sur, Maria Kasper
Cell Reports 2018 25:3, 585-597.e7
Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin
Xiying Fan, Dongmei Wang, Jeremy Evan Burgmaier, Yudong Teng, Rose-Anne Romano, Satrajit Sinha, Rui Yi
Developmental Cell 2018 47:1, 21-37.e5
Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin
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Frontiers in Immunology 2018 9:,
Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis
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Journal of Investigative Dermatology 2018 138:12, 2558-2567
Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations
Christina Philippeos, Stephanie B. Telerman, Bénédicte Oulès, Angela O. Pisco, Tanya J. Shaw, Raul Elgueta, Giovanna Lombardi, Ryan R. Driskell, Mark Soldin, Magnus D. Lynch, Fiona M. Watt
Journal of Investigative Dermatology 2018 138:4, 811-825
Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells
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Genome Biology 2018 19:1,
SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin
Tracy Tabib, Christina Morse, Ting Wang, Wei Chen, Robert Lafyatis
Journal of Investigative Dermatology 2018 138:4, 802-810
A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation
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Immunity 2018 48:6, 1258-1270.e6
Mapping the Mouse Cell Atlas by Microwell-Seq
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Cell 2018 172:5, 1091-1107.e17
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
Nature 2018 562:7727, 367-372
Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis
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JCI Insight 2017 2:9,
Epithelial-Mesenchymal Micro-niches Govern Stem Cell Lineage Choices
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